Sulfobutyl Ether Beta Cyclodextrin Sodium CAS NO. :182410-00-0

SBE-β-CD is a high water-soluble anionic cyclodextrin derivative.It can easily form non-covalent inclusion complexes with drug molecules, thus it has the good performances in enhancing drug stability.


Products Informations

CAS NO. 182410-00-0
Standard USP, In-house Standard
Appearance White powder,sweet,insipid and innocuous
Grade Injection  
Application Pharmaceuticals
Molecular Weight 1347
Solubility ≥100(25℃,g/100ml)  
Heavy metal ≤0.0025%
Shelf life 36 Months 
MOQ 1 kg


Products Application

Sulfobutyl ether beta cyclodextrin sodium ( Betadex sulfobutyl ether sodium, SBE-β-CD ) is a new type of anionic high soluble cyclodextrin derivatives. It could include drug molecules to from covalent compounds so that increase the drug’s stability,solubility,safety.It could reduce the renal toxicity,moderate drug’s hemolysis,control the release rate and cover up the bad smell.

It can be used as a solubilizer,wetting agent,chelating agent (complexing agent) and polyvatent masking agent.

It has been used in injection,oral,nasal and eye medicines.It could has a special affinity and inclusion for nitrogen drugs.

Specification ( USP Standard)



Appearance White to off-white, amorphous powder
Solubility Freely soluble in water and in propylene glycol
Identification IR  The infrared absorption spectrum is consistent with that of the Standard
HPLC The retention time of the major peak of the Sample solution corresponds to that of the Standard solution
Average Degree of Substitution Meets the requirements of the test for Average Degree of Substitution
Sodium Gives the reactions of the Sodium
Clarity The solution is clear and essentially free from particles of  foreign matter
Assay ( % ) 95.0-105.0
Heavy Metals ( ppm ) ≤5
Limit of Beta Cyclodextrin ( Betadex ) ( % ) ≤0.1
Limit of 1,4-Butane Sultone ( ppm ) ≤0.5
Limit of Sodium Chloride ( % ) ≤0.2
Limit of 4-Hydroxybutane-1-sulfonic Acid ( % ) ≤0.09
Limit of and Bis( 4-sulfobutyl )Ether Disodium ( % ) ≤0.05
Bacterial Endotoxins ( EU/g)


The total aerobic microbial ( CFU/g ) ≤100
The total combined molds and yeasts ( CFU/g ) ≤50
Escherichia coli Absent
Average Degree of Substitution 6.2-6.9
Peaks Ⅰ-Ⅹ ( peak area ) Ⅰ   0.0-0.3


pH 4.0-6.8
Water Determination ( % ) ≤10